Licochalcone A is a potent anti-inflammatory and antioxidant active that is derived from the roots of the Chinese licorice plant Glycyrrhiza inflata. Licochalcone A protects cells from oxidative stress mediated by UV and blue light (HEVIS).

Licochalcone A is able to activate anti-inflammatory, antioxidant and detoxifying enzymes. These enzymes protect the skin cells from damage induced by oxidative stress, like lipid peroxidation and DNA as wells as protein damage. Licochalcone A is able to soothe irritated skin and redness.